澳门新葡萄新京app官网网站页头logo

师资队伍
张智军
职务/职称:副教授/硕导
研 究 所:药物化学研究所
联系电话:
电子邮件:zhangzj@lzu.edu.cn
办 公 室:勤博楼2001
  • 个人简介
  • 研究成果
  • 研究项目
  • 【基本情况】

    工作经历:

    2023.11-至今,兰州大学澳门新葡萄新京app官网,副教授,药物化学研究所

    2018.07-2023.10,兰州大学澳门新葡萄新京app官网,讲师,药物化学研究所

    教育经历:

    2015.11-2017.02,中国科学院上海药物研究所(联合培养博士),药物化学

    2014.09-2018.06,华南农业大学,博士,农药合成

    2011.09-2014.06,兰州大学,硕士,药物化学

    2007.09-2011.06,兰州大学,学士,药学

     

    【研究方向】

    基于天然活性分子先导的新型杀菌剂的设计合成与作用机制研究。

     

    【主讲课程】

    承担本科生《有机化学》理论课及实验课教学工作。

     

    【获奖情况】

    2023年7月,作为指导老师之一指导研究生获得工业协会主办的企业揭榜挂帅项目一等奖。


  • (1) Hai-Xin Li, Xiong-Fei Luo, Peng Deng, Shao-Yong Zhang, Han Zhou, Yan Yan Ding, Yi-Rong Wang, Ying-Qian Liu*, and Zhi-Jun Zhang*. Structural Simplification of Cryptolepine to Obtain Novel Antifungal Quinoline Derivatives against Phytopathogenic Fungi. J. Agric. Food Chem., 2023, 71, 2301-2312. (SCI一区Top, IF = 6.1)

    (2) Yan-Yan Ding, Han Zhou, Peng-Deng, Bao-Qi Zhang, Zhi-Jun Zhang*, Guang-Han Wang, Shao-Yong Zhang*, Zheng-Rong Wu, Yi-Rong Wang, Ying-Qian Liu.* Antimicrobial activity of natural and semi-synthetic carbazole alkaloids. Eur. J. Med. Chem., 2023, 259, 115627. (SCI一区Top, IF = 6.7)

    (3) Tian-Lin Wu, Bao-Qi Zhang, Xiong-Fei Luo, An-Ping Li, Shao-Yong Zhang, Jun-Xia An, Zhi-Jun Zhang*, Ying-Qian Liu*. Antifungal efficacy of sixty essential oils and mechanism of oregano essential oil against Rhizoctonia solani. Ind. Crop. Prod., 2023, 191, 115975. (SCI一区Top, IF = 5.9)

    (4) Yan-Yan Ding, Yu Sun, Xiong-Fei Luo, Shao-Yong Zhang, Rui Wang, Zhi-Gang Yang*, Jing-Ru Wang, Bao-Qi Zhang, Zhi-Jun Zhang*, Yue Ma, Jun-Xia An, Han Zhou, Ying-Qian Liu*. Anti-phytopathogenic activity and the mechanisms of phthalides from Angelica sinensis (Oliv.) Diels. Pest Manag. Sci., 2023, 79, 2135-2146. (SCI一区Top, IF = 4.1)

    (5) Yin-Peng Bai, Cheng-Jie Yang, Nan Deng, Mi Zhang, Zhi-Jun Zhang*, Lei Li, Yong Zhou, Xiong-Fei Luo, Chuan-Rui Xu*, Bao-Qi Zhang, Yue Ma, Ying-Qian Liu. Design and synthesis of novel 7-ethyl-10-fluoro-20-O-(cinnamic acid ester)-camptothecin derivatives as potential high selectivity and low toxicity topoisomerase I inhibitors for hepatocellular carcinoma. Biochem. Pharmacol., 2022, 200, 115049. (SCI二区Top, IF = 5.8)

    (6) Yong Zhou, Yin-Peng Bai, Mi Zhang, Jian-Mei Gao, Cheng-Jie Yang, Zhi-Jun Zhang*, Nan Deng, Lei Li, Ying-Qian Liu*, Chuan-Rui Xu*. Design and synthesis of Aza-boeravinone derivatives as potential novel topoisomerase I inhibitors. Bioorg. Chem., 2022, 122, 105747. (SCI一区Top, IF = 5.1)

    (7) Junmin Xi1, Zhijun Zhang1, Zuo Wang†, Qingfeng Wu, Ying He, Yanyi Xu, Zhenjiang Ding, Huanhuan Zhao, Honghong Da, Fang Zhang, Haiyu Zhao*, Jianguo Fang*. Hinokitiol functions as a ferroptosis inhibitor to confer neuroprotection. Free Radic. Biol. Med., 2022, 190, 202-215. (SCI一区Top, IF = 7.4)

    (8) Yong Zhou, Cheng-Jie Yang, Xiong-Fei Luo, An-Ping Li, Shao-Yong Zhang, Jun-Xia An, Zhi-Jun Zhang*, Yue Ma, Bao-Qi Zhang, Ying-Qian Liu*. Design, synthesis, and biological evaluation of novel berberine derivatives against phytopathogenic fungi. Pest Manag. Sci., 2022, 78, 4361-4376. (SCI一区Top, IF = 4.1)

    (9) Xiao-Fei Shang, Li-Xia Dai, Zhi-Jun Zhang*, Cheng-Jie Yang, Sha-Sha Du, Tian-Lin Wu, Ying-Hui He, Jia-Kai Zhu, Ying-Qian Liu*, Yin-Fang Yan, Xiao-Lou Miao, and Ji-Yu Zhang. Integrated proteomics and transcriptomics analyses reveals the possible antifungal mechanism of an indoloquinoline alkaloid neocryptolepine against Rhizoctonia solani. J. Agric. Food Chem., 2021, 69, 6455−6464. (SCI一区Top, IF = 6.1)

    (10) Hu Li, Ying-Hui He, Yong-Mei Hu, Qing-Ru Chu, Yong-Jia Chen, Zhen-Rong Wu, Zhi-Jun Zhang*, Ying-Qian Liu*, Cheng-Jie Yang, Hong-Jie Liang, Yin-Fang Yan, Design, synthesis, and structure−activity relationship studies of magnolol derivatives as antifungal agents. J. Agric. Food Chem., 2021, 69, 11781−11793. (SCI一区Top, IF = 6.1)

    (11) Yu-Dong Yang, Ying-Hui He, Kun-Yuan Ma, Hu Li, Zhi-Jun Zhang*, Yu Sun, Yu-Ling Wang, Guan-Fang Hu, Ren-Xuan Wang, and Ying-Qian Liu*, Design and discovery of novel antifungal quinoline derivatives with acylhydrazide as a promising pharmacophore. J. Agric. Food Chem., 2021, 69, 8347−8357. (SCI一区Top, IF = 6.1)

    (12) Yong-Jia Chen, Kun-Yuan Ma, Sha-Sha Du, Zhi-Jun Zhang*, Tian-Lin Wu, Yu Sun, Ying-Qian Liu*, Xiao-Dan Yin, Rui Zhou, Yin-Fang Yan, Ren-Xuan Wang, Ying-Hui He, Qing-Ru Chu, and Chen Tang, Antifungal exploration of quinoline derivatives against phytopathogenic fungi inspired by quinine alkaloids. J. Agric. Food Chem., 2021, 69, 12156−12170. (SCI一区Top, IF = 6.1)

    (13) Ren-Xuan Wang, Sha-Sha Du, Jing-Ru Wang, Qing-Ru Chu, Chen Tang, Zhi-Jun Zhang*, Cheng-Jie Yang, Ying-Hui He, Hai-Xing Li, Tian-Lin Wu, and Ying-Qian Liu*, Design, synthesis, and antifungal evaluation of luotonin A derivatives against phytopathogenic fungi. J. Agric. Food Chem., 2021, 69, 14467-14477. (SCI一区Top, IF = 6.1)

    (14) Anping Li, Zhongmin Zhao, Shaoyong Zhang, Zhijun Zhang*, Yanping Shi*, Fungicidal activity and mechanism of action of glabridin from Glycyrrhiza glabra L. Int. J. Mol. Sci., 2021, 22, 10966. (SCI二区Top, IF = 5.6)

    (15) Yin-Fang Yan, Tian-Lin Wu, Sha-Sha Du, Zheng-Rong Wu, Yong-Mei Hu, Zhi-Jun Zhang*, Wen-Bin Zhao, Cheng-Jie Yang, Ying-Qian Liu*, The antifungal mechanism of isoxanthohumol from Humulus lupulus Linn. Int. J. Mol. Sci., 2021, 22, 10853. (SCI二区Top, IF = 5.6)

    (16) Ying-Hui He, Xiao-Fei Shang, Hai-Xin Li, An-Ping Li, Chen Tang, Bao-Qi Zhang, Zhi-Jun Zhang*, Rui Wang, Yue Ma, Sha-Sha Du, Yong-Mei Hu, Tian-Lin Wu, Wen-Bin Zhao, Cheng-Jie Yang, Ying-Qian Liu*, Antifungal activity and action mechanism study of coumarins from Cnidium monnieri fruit and structurally related compounds. Chem. Biodivers., 2021, 18, e2100633. (SCI三区, IF = 2.9)

    (17) Zhi-Jun Zhang, Xiao-Fei Shang, Liu Yang, Yan-Bin Shi, Ying-Qian Liu*, Jun-Cai Li, Guan-Zhou Yang, Cheng-Jie Yang. Engineering of peglayted camptothecin into nanomicelles and supramolecular hydrogels for pesticide combination control. Front. Chem., 2020, 7, 922. (SCI二区, IF = 5.5)

    (18) Zi-Long Song, Guan-Zhou Yang, Jun-Cai Li, Ying-Qian Liu*, Chen-Jie Yang, Masuo Goto, Zhi-Jun Zhang*, Susan L. Morris-Natschke, Hua Liu, Kuo-Hsiung Lee*, Design and synthesis of novel 7-[(N-substituted-thioureidopiperazinyl) -methyl]-camptothecin derivatives as potential cytotoxic agents. Nat. Prod. Res., 2020, 34, 2022-2029. (SCI三区, IF = 2.2)

    (19) Jie Zeng†, Zhijun Zhang†,*, Qi Zhu, Zhiyan Jiang, and Guohua Zhong*, Simplification of natural β-carboline alkaloids to obtain indole derivatives as potent fungicides against rice sheath blight. Molecules 2020, 25, 1189. (SCI二区, IF = 4.6)

    (20) Zhi-Jun Zhang, Zhi-Yan Jiang, Qi Zhu, Guo-Hua Zhong*. Discovery of β-carboline oxadiazole derivatives as fungicidal agents against rice sheath blight. J. Agric. Food Chem., 2018, 66, 9598-9607. (SCI一区Top, IF = 6.1)

    (21) Zhi-Jun Zhang, Yong Zeng, Zhi-Yan Jiang, Ben-Shui Shu, Veeran Sethuraman, Guo-Hua Zhong*. Design, synthesis, fungicidal property and QSAR studies of novel β-carbolines containing urea, benzoylthiourea and benzoylurea for the control of rice sheath blight. Pest Manag. Sci., 2018, 74, 1736-1746. (SCI一区Top, IF = 4.1)

    (22) Jing-Jing Zhang1, Zhi-Jun Zhang1, Ben-Shui Shu, Gao-Feng Cui, Guo-Hua Zhong*. Cytotoxic and apoptotic activity of a novel harmine derivative ZC-14 in Sf9 cells. Int. J. Mol. Sci., 2018, 19, 811. (SCI二区Top, IF = 5.6)

    (23) Junmin Xi1, Zhijun Zhang1, Qi Zhu and Guohua Zhong*, Evolution from natural β-carboline alkaloids to obtain 1,2,4,9-tetrahydro-3-thia-9-aza-fluorene derivatives as potent fungicidal agents against Rhizoctonia solani. Int. J. Mol. Sci., 2018, 19, 4044. (SCI二区Top, IF = 5.6)

    (24) Guan-Zhou Yang, Xiao-Fei Shang, Pi-Le Cheng, Xiao-Dan Yin, Jia-Kai Zhu, Ying-Qian Liu*, Jing Zhang*, and Zhi-Jun Zhang*, Facile three-component synthesis, insecticidal and antifungal evaluation of novel dihydropyridine derivatives. Molecules, 2018, 23, 2422. (SCI二区, IF = 4.6)

    (25) Zhi-Jun Zhang, Jing-Jing Zhang, Zhi-Yan Jiang, Guo-Hua Zhong*. Design, synthesis and bioactivity evaluation of novel β-carboline 1,3,4-oxadiazole derivatives. Molecules 2017, 22, 1811. (SCI二区, IF = 4.6)

    (26) Wen-Qun Li1, Zhi-Jun Zhang1, Xiang Nan, Ying-Qian Liu*, Guan-Fang Hu, Hai-Tao Yu, Xiao-Bo Zhao, Dan Wu and Li-Ting Yan. Design, synthesis and bioactivity evaluation of novel benzophenone hydrazone derivatives. Pest Manag. Sci. 2014, 70, 667-673. (SCI一区Top, IF = 4.1)

    (27) Zhi-Jun Zhang, Jing Tian, Li-Ting Wang, Mei-Juan Wang, Xiang Nan, Liu Yang, Ying-Qian Liu*, Susan L. Morris-Natschke and Kuo-Hsiung Lee*. Design, synthesis and cytotoxic activity of novel sulfonylurea derivatives of podophyllotoxin. Bioorg. Med. Chem., 2014, 22, 204-210. (SCI三区, IF = 3.5)

    (28) Liu Yang1, Zhi-Jun Zhang1, Ying-Qian Liu*, Chun-Yan Zhao, Mei-Juan Wang, Xiang Nan, Gang Feng*. Evaluation of insecticidal activity of camptothecin analogs against Brontispa longissima. Med. Chem. Res. 2014, 23, 980-986. (SCI四区, IF = 2.6)


  • (1) 国家自然科学基金青年项目,32302390,负责人;

    (2) 甘肃省自然科学基金项目,20JR5RA216,负责人;

    (3) 中央高校优秀青年教师科研创新项目,lzujbky-2022-37,负责人;

    (4) 中央高校基本科研自由探索项目,lzujbky-2019-27,负责人;

    (5) 国家自然科学基金面上项目,22177043,参与;

    (6) 国家自然科学基金面上项目,31871988,参与;

    (7) 国家自然科学基金青年项目,31701812,参与;

    (8) 甘肃省科技计划基础研究创新群体项目,20JR5RA311,参与;

    (9) 甘肃省重点研发计划项目,23YFFA0007,参与。


电话:0931-8915686 地址:兰州市城关区东岗西路199号  陇ICP备10000336号  

Copyrights © All Rights Reserved. 版权所有 澳门新葡萄新京app官网(中国)股份有限公司-SouGou百科

师德师风举报电话:8915681

师德师风举报邮箱:caoxi@lzu.edu.cn

事业单位
澳门新葡萄新京app官网网站底部二维码